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All participants received lifestyle intervention alongside medication or placebo

Additionally, as Zepbound promotes weight loss through reduced appetite and caloric intake, some patients may inadvertently decrease their fluid consumption alongside food intake

Lancet (2026)

Why illegal supply is a serious medical risk The MHRA reported that it dismantled a major illicit manufacturing facility in Northampton and described the seizure as the largest single seizure of trafficked weight-loss medicines worldwide , while warning that retatrutide products sold in the UK outside trials are likely illegal and potentially dangerous (MHRA announcement on illicit weight-loss medicine production)

Patti, G